Derivation of iPSC lines from two patients with autism spectrum disorder carrying NRXN1α deletion (NUIGi041-A, NUIG041-B; NUIGi045-A) and one sibling control (NUIGi042-A, NUIGi042-B)

NRXN1 encodes thousands of splicing variants categorized into long NRXN1α, short NRXN1β and extremely NRXN1γ, which exert differential roles in neuronal excitation/inhibition. NRXN1α deletions are common autism spectrum disorder (ASD) other neurodevelopmental/neuropsychiatric disorders. We derived induced pluripotent stem cells (iPSCs) from one sibling control two ASD probands carrying NRXN1α+/−, using non-integrating Sendai viral method. All iPSCs highly expressed pluripotency markers could be differentiated ectodermal/mesodermal/endodermal cells. The genotype karyotype the were validated by whole genome SNP array. availability offers an opportunity for understanding function human neurons ASD.